Helicon Focus has been working quite well for me in processing multiple images made with a digital single lens reflex camera (Olympus E-volt) and stereo microscope or metallograph.
Recently I have been processing large numbers of images of a single field - forty-nine, 8 megapixel images as the extreme example. Today I processed over a thousand such images, twenty-eight such fields, to be exact. After I finished without incident, I closed Helicon Focus and restarted the Dell Inspiron 1545 laptop. The restart was uneventful, but when I opened Helicon Focus again, I got the following error message: "Access violation at address 7C910A19 in module ntdll.dll read of address CACCAC02." I cancelled the error message and tried starting Helicon Focus again, whereupon another error message appeared: "Internal error ! out of memory."
This sort of thing has happened before with this version of Helicon Focus over the last few days. Each time I uninstall Helicon Focus, reinstall an earlier version (approximately February 2010) and then download the latest version from the Helicon Focus menu. That gets Helicon Focus working again, but it's far too tedious to do this on a routine basis.
Sometimes the error message blames HeliconFocus.exe; other times, it's ntdll.dll again.
Processing fewer images seems not to be so troublesome; I never encountered errors while processing images from the stereo microscope, where I use a dial indicator to space the imaging distances uniformly. With the metallograph and a 21X objective and taking pictures of the polished and etched surface of a piece of stainless steel tube that's fifteen feet long and not aligned well with the microscope axis, I have a lot more images, each one one micron (0.001 mm) apart from the next, using the fine focus graduations. The end results are great, not just with the sharpened image, but also with the animated image and the stereo images. But Helicon Focus eventually freezes and has to be uninstalled and reinstalled as described above.